This volume draws together academics and think tank experts to explore the revised European Neighborhood Policy (ENP) and EU Global Strategy (EUGS) towards the Southern Neighborhood, in the context of the Arab Uprisings and conflict, counter-terrorism cooperation, the Mediterranean refugee crisis, energy developments in the Eastern Mediterranean, shifting interactions with and between international partners, and the fallout from Covid-19. Covering aspects such as actorness, power and alliances, history, socioeconomics, domestic politics, regime security, and the regional security complex, the authors provide a comprehensive and theoretically rich analysis of EU policy inputs, southern neighborhood interests and responses, as well as new strategy proposals aimed at enhancing human security. The volume will appeal to European and Middle East studies students, international relations scholars and policy professionals alike.