Digital innovations influence every aspect of life in an increasingly digitalized world. Firms pursuing digital innovations must consider how digital technologies shape the nature, process and outcomes of innovation as well as long- and short-term social, economic and cultural consequences of their offerings. This Handbook contributes to a transdisciplinary understanding of digital innovation with a diverse set of leading scholars and their distinct perspectives. The ideas and principles advanced herein set the agenda for future transdisciplinary research on digital innovation in ways that inform not only firm-level strategies and practices but also policy decisions and science-focused investments.